Clindamycin and Benzoyl Peroxide Gel (generic Duac)

What is Clindamycin and Benzoyl Peroxide gel?

Clindamycin and Benzoyl Peroxide gel is a topical medication used primarily for the treatment of acne vulgaris, a common skin condition characterized by clogged pores, inflammation, and sometimes bacterial infection.

How does Clindamycin and Benzoyl Peroxide work?

Clindamycin: Clindamycin is an antibiotic that works by inhibiting the growth of acne-causing bacteria on the skin. It belongs to the lincosamide class of antibiotics and is effective against certain types of bacteria, particularly Propionibacterium acnes, which is often involved in the development of acne.

Benzoyl Peroxide: Benzoyl Peroxide is a topical medication with both antimicrobial and keratolytic properties. It works by killing bacteria on the skin's surface and within pores, while also helping to remove dead skin cells and excess oil. This helps to prevent the formation of new acne lesions and promote the healing of existing ones.

When combined in a gel formulation, Clindamycin and Benzoyl Peroxide work synergistically to target multiple factors contributing to acne development, including bacteria, inflammation, and excess oil production. This combination is often prescribed by dermatologists for moderate to severe cases of acne vulgaris. It's usually applied once or twice daily to affected areas of the skin after cleansing.

Are there alternative acne treatments?

Yes, there are several alternative acne treatments available, depending on the severity of the acne and individual factors such as skin type and tolerance to certain medications. Some alternative treatments include:

1. Topical Retinoids: Retinoids are derivatives of vitamin A that help unclog pores, reduce inflammation, and promote the turnover of skin cells. They are available in various forms, including creams, gels, and lotions, and are often used as a first-line treatment for acne.
2. Salicylic Acid: Salicylic acid is a beta hydroxy acid that helps exfoliate the skin, unclog pores, and reduce inflammation. It's commonly found in over-the-counter acne products such as cleansers, toners, and spot treatments.
3. Azelaic Acid: Azelaic acid is a naturally occurring acid found in grains such as barley, wheat, and rye. It has antimicrobial and anti-inflammatory properties and is effective in treating acne, especially for those with sensitive skin or who cannot tolerate other acne medications.
4. Oral Antibiotics: In cases of moderate to severe acne, oral antibiotics such as doxycycline, minocycline, or tetracycline may be prescribed to help reduce inflammation and kill acne-causing bacteria. These medications are typically used for a short period to avoid the development of antibiotic resistance.
5. Hormonal Therapy: For women with hormonal acne, oral contraceptives (birth control pills) or anti-androgen medications may be prescribed to regulate hormone levels and reduce acne flare-ups.
6. Isotretinoin (Accutane): Isotretinoin is a powerful oral medication reserved for severe, treatment-resistant acne. It works by reducing oil production, preventing clogged pores, and reducing inflammation. Isotretinoin is highly effective but also has potentially serious side effects, so it's usually prescribed under close medical supervision.
7. Light and Laser Therapy: Light-based therapies such as blue light, red light, or photodynamic therapy (PDT) may be used to target acne-causing bacteria, reduce inflammation, and promote healing.

It's essential to consult with a healthcare provider or dermatologist to determine the most suitable treatment option based on the individual's specific needs and the type and severity of acne. Additionally, maintaining a consistent skincare routine, avoiding triggers such as harsh skincare products or excessive sun exposure, and practicing good hygiene can also help manage acne symptoms.

How does this differ from Duac?

Duac is a brand-name medication that contains two active ingredients: Clindamycin Phosphate and Benzoyl Peroxide. It is primarily used for the topical treatment of acne vulgaris.

The generic version of Duac contains the same active ingredients, Clindamycin phosphate and Benzoyl Peroxide, but it is typically sold under its chemical names rather than a brand name. Generic medications are approved by regulatory agencies, such as the MHRA, as equivalent to the brand-name drug in terms of safety, efficacy, dosage, strength, route of administration, quality, and intended use.

The main difference between Duac and its generic version lies in their branding and pricing. Brand-name medications like Duac are usually more expensive than their generic counterparts because brand-name companies invest in research, development, and marketing of the drug. Once the patent protection for the brand-name drug expires, other pharmaceutical companies can produce generic versions, which often results in lower prices due to competition.

In terms of effectiveness and side effects, Duac and its generic version should be equivalent since they contain the same active ingredients in the same concentrations. However, inactive ingredients (excipients) such as preservatives, fragrances, or stabilisers may differ between the brand-name and generic versions.

While these differences are typically minor and do not affect the medication's overall performance, individuals with sensitivities or allergies to certain ingredients may find that they prefer one formulation over the other.

Do I have to keep Clindamycin and Benzoyl Peroxide in the fridge?

No. While at the pharmacy it is stored in the fridge. Once it has been provided to you it can be safely stored at room temperature but make sure it's not kept in a place where it can get too hot, above 25°C. At room temperature, it can be stored for 2 months. At the correct dose, this will be longer than the cream will last.

If you have ordered more than 1 tube. We would recommend that you store the unused creams in the fridge between 2°C to 8°C. But don't freeze it.

Sources

• Patient Information Leaflet
  

How to apply Clindamycin & Benzoyl Peroxide Gel

To apply Clindamycin and Benzoyl Peroxide gel effectively, follow these general steps:

1. Cleanse your skin: Before applying the gel, wash your face gently with a mild cleanser and pat it dry with a clean towel. Avoid harsh scrubbing or abrasive cleansers, as they can irritate the skin and worsen acne.
2. Apply a small amount: Squeeze a pea-sized amount of the gel onto your fingertip or a clean applicator. A little goes a long way, so you don't need to apply a thick layer. Start with a small amount and increase if necessary.
3. Dot the gel onto affected areas: Use your fingertip or applicator to dot the gel onto the areas of your skin affected by acne. Focus on areas where you typically experience breakouts or have active pimples.
4. Gently massage in: Using clean fingertips, gently massage the gel into your skin until it's absorbed. Be careful not to rub too vigorously, as this can irritate the skin. Allow the gel to dry completely before applying any other skincare products or makeup.
5. Wash your hands: After applying the gel, wash your hands thoroughly to remove any residue and prevent accidentally transferring the medication to other areas of your skin or eyes.
6. Use as directed: Follow your healthcare provider's instructions regarding the frequency and duration of application. Clindamycin and Benzoyl Peroxide gel is typically applied once or twice daily, but your doctor may adjust the dosage based on your individual needs and response to treatment.
7. Be consistent: Consistency is key when using acne medications. Stick to your prescribed regimen and continue using the gel even if you don't see immediate results. It may take several weeks to notice improvements in your acne, so be patient and stay consistent with your skincare routine.
8. Monitor for side effects: Pay attention to how your skin reacts to the medication. Some common side effects of Clindamycin and Benzoyl Peroxide gel include dryness, redness, peeling, or irritation. If you experience severe or persistent side effects, consult your healthcare provider.

How long does it take to work?

The time it takes for Clindamycin and Benzoyl Peroxide Gel to reduce your acne symptoms will depend on the condition of your skin and whether you have moderate acne or severe acne. In some cases, it proves highly impactful and makes a visible difference within days, but it normally takes between two and four weeks to yield significant results.

The longer you use the gel, the better the results will be. Following a full 12 week course is most likely to effectively combat your acne, but you mustn’t exceed 12 weeks unless advised to do so by your doctor. Too much Clindamycin and Benzoyl Peroxide Gel can cause antibiotic resistance where bacteria build up resistance to the antibiotics designed to fight them.

Clindamycin and Benzoyl Peroxide Gel ingredients

The active substances in Clindamycin and Benzoyl Peroxide Gel are: clindamycin and hydrous benzoyl peroxide.

The other ingredients are: Carbomer (50000mPa.s), Dimeticone (100mm².s^-1), Disodium Lauryl Sulfosuccinate, Edetate Disodium, Glycerol, Silica, Colloidal Hydrated, Poloxamer 182, Purified Water, Sodium Hydroxide

Clindamycin & Benzoyl Peroxide Gel side effects

The three main side effects of Clindamycin and Benzoyl Peroxide gel are typically:

1. Skin Irritation: One of the most common side effects of this medication is skin irritation. This can manifest as redness, itching, burning, or stinging at the application site. In some cases, the skin may also become dry, flaky, or peel. It's essential to monitor your skin's reaction to the gel and report any severe or persistent irritation to your healthcare provider.
2. Dryness: Both Clindamycin and Benzoyl Peroxide can have drying effects on the skin, especially when used in combination. This can lead to dryness, flakiness, or a feeling of tightness in the treated areas. Using a gentle moisturiser can help alleviate dryness and prevent excessive irritation.
3. Increased Sensitivity to Sun: Benzoyl Peroxide, in particular, can make the skin more sensitive to sunlight. Prolonged or excessive sun exposure while using Clindamycin and Benzoyl Peroxide gel may increase the risk of sunburn, skin damage, and premature ageing. It's important to use sunscreen with a high SPF and to limit sun exposure, especially during peak hours, while using this medication.

It's important to note that while these are common side effects, not everyone will experience them, and some individuals may tolerate the medication well. However, if you experience severe or persistent side effects, or if you develop any signs of an allergic reaction (such as rash, swelling, or difficulty breathing), it's crucial to seek medical attention promptly.

Clindamycin and Benzoyl Peroxide gel warnings

Like any medication, Clindamycin and Benzoyl Peroxide gel comes with specific warnings for use. Here are some important warnings associated with this medication:

1. Skin Irritation: As mentioned earlier, skin irritation is a common side effect of Clindamycin and Benzoyl Peroxide gel. This may include redness, itching, burning, or stinging at the application site. If excessive irritation occurs, the frequency of application may need to be reduced, or the medication may need to be temporarily discontinued. Avoid using other potentially irritating products, such as harsh cleansers or exfoliants, while using this medication unless directed by your healthcare provider.
2. Avoid Contact with Eyes, Mouth, and Mucous Membranes: Clindamycin and Benzoyl Peroxide gel should not come into contact with the eyes, mouth, or mucous membranes (such as inside the nose). If accidental contact occurs, rinse the affected area thoroughly with water. Avoid applying the gel to areas of broken or irritated skin, as this may increase the risk of irritation or absorption of the medication into the bloodstream.
3. Sun Sensitivity: Benzoyl Peroxide, one of the active ingredients in this medication, can make the skin more sensitive to sunlight. Prolonged or excessive sun exposure while using Clindamycin and Benzoyl Peroxide gel may increase the risk of sunburn, skin damage, and premature aging. It's essential to use sunscreen with a high SPF and to limit sun exposure, especially during peak hours, while using this medication.
4. Allergic Reactions: Some individuals may be allergic to Clindamycin or Benzoyl Peroxide, or other ingredients in the gel. Signs of an allergic reaction may include rash, itching, swelling, dizziness, or difficulty breathing. If you experience any signs of an allergic reaction, discontinue use of the medication and seek medical attention immediately.
5. Pregnancy and Breastfeeding: The safety of Clindamycin and Benzoyl Peroxide gel during pregnancy and breastfeeding has not been well established. If you are pregnant, planning to become pregnant, or breastfeeding, it's essential to discuss the risks and benefits of using this medication with your healthcare provider before starting treatment.
6. Avoid Using with Certain Products: Clindamycin and Benzoyl Peroxide gel may interact with certain other topical medications or skincare products. Avoid using other acne medications or products containing sulfur, resorcinol, or salicylic acid while using this medication unless directed by your healthcare provider.